Transcriptomic Analysis Identifies Phosphatases as Novel Targets for Adenotonsillar Hypertrophy of Pediatric Obstructive Sleep Apnea
نویسندگان
چکیده
منابع مشابه
Obstructive sleep apnea syndrome due to adenotonsillar hypertrophy in infants.
OBJECTIVE Adenotonsillar hypertrophy (ATH) is the leading cause for obstructive sleep apnea syndrome (OSAS) in children. The peak age for adenoid and tonsillar hypertrophy and related OSAS is 3-6 years. It has been suggested that OSAS due to ATH is extremely rare in infants. The purpose of the present study was to delineate OSAS due to ATH in infants. METHODS Twenty-nine consecutive infants <...
متن کامل[Obstructive sleep apnea-hypopnea syndrome in children: beyond adenotonsillar hypertrophy].
The prevalence of obstructive sleep apnea-hypopnea syndrome in the general childhood population is 1-2% and the most common cause is adenotonsillar hypertrophy. However, beyond adenotonsillar hypertrophy, there are other highly prevalent causes of this syndrome in children. The causes are often multifactorial and include muscular hypotonia, dentofacial abnormalities, soft tissue hypertrophy of ...
متن کاملAdenotonsillar hypertrophy and skeletal morphology of children with obstructive sleep apnea syndrome.
To define the role of adenotonsillar hypertrophy and facial morphology in obstructive sleep apnea (OSA) in children we performed a cephalometric analysis of an OSA group and an age-matched control group. Adenotonsillar hypertrophy was remarkable in OSA children at every age level. Maxillary protrusion expressed by SNA was significantly smaller in the OSA group than in the control group for elde...
متن کاملComparison of polygraphic parameters in children with adenotonsillar hypertrophy with vs without obstructive sleep apnea.
OBJECTIVE To compare the polygraphic parameters in children with adenotonsillar hypertrophy (ATH) with vs without obstructive sleep apnea (OSA). DESIGN Prospective controlled study. SETTING Hospital-based pediatric otolaryngology practice. PATIENTS Children with ATH. INTERVENTIONS The children enrolled in the study underwent polysomnography. According to the apnea index (AI) (a patient ...
متن کاملAssociations between Adenotonsillar Hypertrophy, Age, and Obesity in Children with Obstructive Sleep Apnea
OBJECTIVE To investigate the contributions of adenoid and tonsil size to childhood obstructive sleep apnea (OSA) and the interactions between adenotonsillar hypertrophy, age, and obesity in children with OSA. METHODS In total, 495 symptomatic patients were recruited. The patients were assigned to four groups according to age: toddler (age 1-3, n=42), preschool (age 3-6, n=164), school (age 6-...
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ژورنال
عنوان ژورنال: American Journal of Respiratory and Critical Care Medicine
سال: 2010
ISSN: 1073-449X,1535-4970
DOI: 10.1164/rccm.200909-1398oc